When doing remote front page debugging using visual studio 2008 in windows 2003 or windows 2008, one might found the breakpoint in the script cannot be hit. A likely reason is that we need to turn off Internet Explorer Enhanced Security Configuration on the machine.
To turn off the IE Enhanced Security Configuration in win2k3, go to control panel->Add or remove programs->Add/Remove Windows Components, uncheck “Internet Explorer Enhanced Security Configuration”.
To turn off the IE Enhanced Security Configuration in win2k8. go to Server Manager > Security Information > Configure IE ESC, one have a choice to disable it only for Administrators.
SDETII | Visual Web Developer