I am a long time "LucasArts Adventure Game" junky – and own *almost* all of their adventure games. Indiana Jones and the Last Crusade: The Graphic Adventure (hereafter referred to as "the Last Crusade") is one of the earlier games in this category (I believe it was the 4th adventure game released by LucasArts). The Last Crusade was a great game in its day. VGA graphics, MIDI sound and an easy to use "point and click" interface.
The thing that always amazed me about this game was that it managed to both follow the movie story line, but remain engaging to play. This is a feat rarely achieved by computer games based on movies.
This game runs well on Virtual PC – however I have found that it occasionally fails with a "divide error" when launched – but succeeds on subsequent attempts to start.
P.S. Yes – I am well aware of ScummVM and have used it to play LucasArts games on many different systems, but as I work on virtualization at Microsoft I am more interested in talking about my own products.