Saw this posted on one of the internal forums today, and I thought this was something that was worth sharing. If you're a keyboard junkie, you'll love this.
Do you have a few applications that you're always firing up? Would you like a system-wide keyboard shortcut to run them? Here's what you do. Simply add shortcuts to the Quick Launch toolbar, as shown in the screenshot below.
Now you can simply use Win+1, Win+2, Win+3 and so on to launch each application. For example, on my machine, Win+3 launches Notepad and Win+6 launches the VS command prompt. This works no matter what application has the focus.
More coolness coming your way soon, courtesy of Windows Vista!