A new tool to correct DNA sequencing errors using consensus and context

The following blog is from guest contributor Paul Greenfield of CSIRO, Australia’s national science agency. He and his colleagues have developed a new correction tool to address the problem of DNA sequencing errors in biological and ecological research, and they have just released it to the research community worldwide. —Simon Mercer, Director, Microsoft Research  …


Building a .NET Quality Control Tool for Next-Generation Sequencing Technologies

The challenge of DNA sequencing is central to all genomics research, and while the technology has existed since the 1970s, today’s massively-parallel sequencing instruments are capable of producing gigabytes of raw genomic data quickly and increasingly cheaply. Reconstruction of a DNA sequence from this data (for example, through de novo assembly) is a compute-intensive task,…