If there's something that I detest while working on my computer is having to switch between mouse and keyboard. Depending on what I'm doing, I'll typically have a keyboard-centric or mouse-centric approach.
For example, coding is very much a keyboard-centric approach, and I very much dislike having to use the mouse for anything.
Browsing, on the other hand, is largely a mouse-centric thing I do. I still haven't found anything that allows me to navigate links with the keyboard as effectively as I can with the mouse.
Being a mouse-centric experience, all that I can do to keep using the mouse just makes things better. If you haven't checked out Mouse Gestures for Internet Explorer, that's a pretty nifty add-on. I haven't had problems with it so far,
Of course these opinions are mine and are not meant to represent those of my employer.