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Assemblies in LoadFrom context can’t be domain neutral. Also they can’t use NGEN.
What is so special about assemblies in LoadFrom context that they can’t be the same as assemblies in the default load context?
For one thing, assemblies in LoadFrom context are order dependent. You can’t predict where its dependencies will come from.
That means assemblies in LoadFrom context can’t have concepts requiring dependencies predictability.
Unfortunately both domain neutral assemblies and NGEN require dependencies predictability.