Using the COM object model exposed by Excel, we can programmatically open files, generate graphs, and save them as stand-alone image files.
Handily, the functionality provided by Excel gives us a simple way to generate charts and graphs when you need something easy and automatable. This is great for creating visualizations for automated reports, web pages, and the like (especially when "offline" or when you have limited access to various other utilities). Unfortunately, the main drawback to using the COM interface is that documentation is often limited and hard to find (especially now that everything has been .NETized), to help remedy this I've linked some references from MSDN below.
var excel = WScript.CreateObject("Excel.Application");
// no we don't want to show the Excel window
excel.Visible = false;
// open the file
var sheet = excel.Workbooks(1).Worksheets(1);
// select both rows of data
// create the chart and setup some options
var chart = excel.Charts.Add(sheet);
chart.ChartType = 4; // 2D line (XlChartType::xlLine)
chart.HasLegend = true;
chart.Axes(1).HasTitle = false;
chart.Axes(2).HasTitle = false;
// save the large chart
// move the chart onto the main sheet
var ptr = chart.Location(2, sheet.Name);
// save the smaller chart
// close out the Excel spreadsheet and application
excel.ActiveWorkbook.Saved = true; // suppress the "save" dialog
And FYI, the type library information is located in excel.exe (in Office 2007) so you can open that file in a viewer (such as oleview.exe) to see all the COM interfaces, enumerations, etc.