This is my current list from a business perspective (not the 110001 bits -maybe next blog post?) and it works out-of-the-box.
Auto-resolution start writing and press (ALT CTRL - K) for suggestions in your lookup box (Try it on customer field in opportunity form)
Converting an Activity (email) to a lead, case ect
Run reports in offline mode + Report wizard
MUI (Multilingual User Interface)
Displaying attributes from related records in your personal views (1 to Many Relationship)
Background synchronization for outlook offline client
Almost on the list is promote more than 1 item from outlook (max20) at a time, synchronize phonecalls, send a hyperlink to current record, mailmerge and "Diagnostic tool for outlook" which I only so far has been reading about but it looks promising.
When I now think about this maybe I should have done a "20 nice features" list??