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The No Managed Code setting for the application is clear in the TechNet page https://technet.microsoft.com/library/hh831797.aspx as stating to use this setting for applications that will NOT use the .NET framework.
By selecting the version of the .NET framework for the application, the worker process will load the version of the CLR for the application to run correctly.
The No Managed Code setting for the application pool is meant to run scripting engines like ASP as the CLR will NOT be loaded in the worker process and may improve performance of the start up for the worker process.
Just make sure the ASP code is not making a code reference to a .NET resource.
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