This is going to be a brief one. If you are using LINQ to SQL, you should check out Damien’s new templated code generator sample. One of our regrets from LINQ to SQL V1 days was not providing an easy way to tailor the code-gen. This is one step in that direction.
Another major step would be to preserve “excluded” tables/columns/sprocs/… in dbml. So any change in schema can be handled appropriately as new/deleted database object (a rename could be treated as a removed column and an added column from metadata perspective).