Microsoft does a good job about sharing best practices from their own IT department in a content series they call It Showcase.
Takle a look at this Showcase link on TechNet for articles on how Microsoft's IT build line of business applications, manages email and user experience and how they do it securely.
You may also want to consider attending this webcast from John Albertson
IT Manager Webcast: How Microsoft IT Secures Mobile Devices (Level 200)
Thursday, April 10, 2008 9:30 AM Pacific Time (US & Canada)
Join this webcast and find out how Microsoft IT is empowering the mobile workforce via the deployment of the Windows Mobile platform. Microsoft IT fully integrates Windows Mobile features and applications, with both established hardware and infrastructure, and future plans support master security policy migrations, such as complete two-factor authentication operations.