I found this wonderful article, which discusses the top support issues for the Microsoft Exchange 2000 & 2003 Server information stores.
This article lists references to Microsoft Knowledge Base articles that describe the issues that may occur when you use the Microsoft Exchange information stores. Additionally, this article lists references to Microsoft Knowledge Base articles that discuss how to troubleshoot issues that you may experience.
This article does not provide a complete list of all the support issues for the Exchange information stores, but certainly it will be a eye opener or will fit into 'generic starter' soup!!