Is it supported to write Windows Shell Extension using .NET 4 today?

Prior to .NET Framework 4, the development of in-process shell extensions using managed code is not supported at all because of the CLR limitation allowing only one .NET runtime per process. Jesse Kaplan, one of the CLR program managers, explains it in this MSDN forum thread:
https://social.msdn.microsoft.com/forums/en-US/netfxbcl/thread/1428326d-7950-42b4-ad94-8e962124043e.

In .NET 4, with the ability to have multiple runtimes in process with any other runtime.  However, writing managed shell extensions is still not supported.  Microsoft recommends against writing them.