If there's a topic related to the CLR, feel free to drop me a line asking me to talk about it. I have a very time-consuming day job and a full life outside of work, so expect a long delay before I address your topic. Or I might feel I have nothing interesting to say about it...But you never know.
Obviously I can't help you with stuff like "I'm trying to get my Web Service working with Passport and..." or "While I'm waiting for a Mouse Up during a drag operation..."
I'm more suited to questions like, "How do you maintain type safety when you dispatch methods on value types, since the instances aren't self-describing?"