If you have not heard already Microsoft has announced a new version of SQL Server 2000 and 2005. The new version, SQL Server Workgroup Edition fills a hole that lots of Visual Basic developers and consultants have run into.
With Visual Basic you can build data-driven application against MSDE for small to mid-size companies on a fixed budget, however there was a bit of sticker shock when you wanted to scale up to SQL Server Standard and purchase licenses.
SQL Server Workgroup provides a step in between at a much more affordable price to many smaller clients you might have. It also works great if you are building application for a department or work group inside of a larger company but don't need the power of SQL Standard but hate the performance restrictions of MSDE.
Read about it here.