Check out this cool article on Coding4Fun that shows you how you can control the Wiimote (the Nintendo Wii’s remote) with Visual Basic code via BlueTooth! This article specifically shows how you can use the Wiimote and the nunchuck to control a custom Virtual Earth Winforms application. Code examples are shown in both Visual Basic and C#.
You can also jump directly to this article which explains how to use the managed Wiimote library in any .NET app you can dream up. You don’t need the game console, just the controllers. (I really want the game console though! :-))